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3 plasmids (pGL1124, pGL1224 and pGL1217) have been made to enable the substitution of one allele of CYC9, is distribute via the tsetse fly and triggers trypanosomiasis in humans and animals. The two the lifetime cycle and mobile cycle from the parasite are intricate. Trypanosomes have eleven cdc2-similar kinases (CRKs) and 10 cyclins, an unusually